Aberrant Frequency of IL-10-Producing B Cells and Its Association with TregTh17 in Adult Primary Immune Thrombocytopenia Patients
المؤلفون المشاركون
Gao, Song
Zou, Shanhua
Li, Ying
Li, Feng
Chen, Lihang
Hua, Fanli
Cheng, Yunfeng
Zhan, Yanxia
Ji, Lili
Chen, Hao
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Regulatory B cells (Breg) are a distinct B cell subset with immunoregulatory properties.
Pivotal to Breg function is interleukin-10.
This study was to investigate the role of IL-10-producing B cell (B10) and its association with Treg and Th17 subsets in immune thrombocytopenia (ITP) patients.
Methods.
Peripheral blood mononuclear cells from ITP patients and controls were stimulated with PMA, ionomycin, and Brefeldin A.
The frequencies of CD19+IL-10+ B cells, CD3+CD4+IL-17+ Th17 cells, and CD4+CD25hiFoxp3+ Treg cells were analyzed by flow cytometry.
The mRNA expression of Foxp3 and RORγt was detected by real-time quantitative PCR.
Results.
The number of B10 cells was elevated in ITP patients.
After first-line therapies, it remained at high level in patients who achieved complete or partial response but decreased in those who acquired no response.
There was a positive correlation between B10 cells and Tregs in ITP both before and after therapies.
The ratio of Treg/Th17 decreased in ITP, and it strongly correlated with B10 cells.
Conclusions.
The frequency of B10 cells is elevated in ITP and it correlates with both the Tregs counts and the Treg/Th17 ratio.
B10 cells to regulate functional T cell subsets might be impaired in patients with ITP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hua, Fanli& Ji, Lili& Zhan, Yanxia& Li, Feng& Zou, Shanhua& Chen, Lihang…[et al.]. 2014. Aberrant Frequency of IL-10-Producing B Cells and Its Association with TregTh17 in Adult Primary Immune Thrombocytopenia Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481644
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hua, Fanli…[et al.]. Aberrant Frequency of IL-10-Producing B Cells and Its Association with TregTh17 in Adult Primary Immune Thrombocytopenia Patients. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481644
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hua, Fanli& Ji, Lili& Zhan, Yanxia& Li, Feng& Zou, Shanhua& Chen, Lihang…[et al.]. Aberrant Frequency of IL-10-Producing B Cells and Its Association with TregTh17 in Adult Primary Immune Thrombocytopenia Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481644
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481644
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر