Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat
المؤلفون المشاركون
Vasconcelos, Silvânia Maria Mendes
Rodrigues, Francisca Taciana Sousa
Viana, Glauce Socorro de Barros
De Sousa, Caren Nádia Soares
de Araújo, Dayane Pessoa
Patrocínio, Manoel Claúdio Azevedo
Aguiar, Lissiana Magna Vasconcelos
Lima, Nicole Brito Cortez
Araújo, Paulo Victor Pontes
Menezes, Carlos Eduardo de Souza
Escudeiro, Sarah Souza
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study aimed to investigate behavioral and neurochemical effects of α-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum.
Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test.
Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity.
α-Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test.
α-lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity.
Therefore, α-lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting that α-lipoic could be a new therapeutic target for Parkinson's disease prevention and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Araújo, Dayane Pessoa& De Sousa, Caren Nádia Soares& Araújo, Paulo Victor Pontes& Menezes, Carlos Eduardo de Souza& Rodrigues, Francisca Taciana Sousa& Escudeiro, Sarah Souza…[et al.]. 2013. Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-481655
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Araújo, Dayane Pessoa…[et al.]. Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-481655
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Araújo, Dayane Pessoa& De Sousa, Caren Nádia Soares& Araújo, Paulo Victor Pontes& Menezes, Carlos Eduardo de Souza& Rodrigues, Francisca Taciana Sousa& Escudeiro, Sarah Souza…[et al.]. Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-481655
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481655
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر