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Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat
Joint Authors
Vasconcelos, Silvânia Maria Mendes
Rodrigues, Francisca Taciana Sousa
Viana, Glauce Socorro de Barros
De Sousa, Caren Nádia Soares
de Araújo, Dayane Pessoa
Patrocínio, Manoel Claúdio Azevedo
Aguiar, Lissiana Magna Vasconcelos
Lima, Nicole Brito Cortez
Araújo, Paulo Victor Pontes
Menezes, Carlos Eduardo de Souza
Escudeiro, Sarah Souza
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study aimed to investigate behavioral and neurochemical effects of α-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum.
Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test.
Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity.
α-Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test.
α-lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity.
Therefore, α-lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting that α-lipoic could be a new therapeutic target for Parkinson's disease prevention and treatment.
American Psychological Association (APA)
de Araújo, Dayane Pessoa& De Sousa, Caren Nádia Soares& Araújo, Paulo Victor Pontes& Menezes, Carlos Eduardo de Souza& Rodrigues, Francisca Taciana Sousa& Escudeiro, Sarah Souza…[et al.]. 2013. Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-481655
Modern Language Association (MLA)
de Araújo, Dayane Pessoa…[et al.]. Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-481655
American Medical Association (AMA)
de Araújo, Dayane Pessoa& De Sousa, Caren Nádia Soares& Araújo, Paulo Victor Pontes& Menezes, Carlos Eduardo de Souza& Rodrigues, Francisca Taciana Sousa& Escudeiro, Sarah Souza…[et al.]. Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-481655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481655