The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis

المؤلفون المشاركون

Samavat, Shiva
Kalantari, Shiva
Zubarev, Roman A.
Rezaei-Tavirani, Mostafa
Rutishuser, Dorothea
Nafar, Mohsen

المصدر

International Journal of Nephrology

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-03-26

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Background.

Focal segmental glomerulosclerosis (FSGS) is a glomerular injury with various pathogenic mechanisms.

Urine proteome panel might help in noninvasive diagnosis and better understanding of pathogenesis of FSGS.

Method.

We have analyzed the urine sample of 11 biopsy-proven FSGS subjects, 8 healthy controls, and 6 patients with biopsy-proven IgA nephropathy (disease controls) by means of liquid chromatography tandem mass spectrometry (nLC-MS/MS).

Multivariate analysis of quantified proteins was performed by principal component analysis (PCA) and partial least squares (PLS).

Results.

Of the total number of 389 proteins, after multivariate analysis and additional filter criterion and comparing FSGS versus IgA nephropathy and healthy subjects, 77 proteins were considered as putative biomarkers of FSGS.

CD59, CD44, IBP7, Robo4, and DPEP1 were the most significant differentially expressed proteins.

These proteins are involved in pathogenic pathways: complement pathway, sclerosis, cell proliferation, actin cytoskeleton remodeling, and activity of TRPC6.There was complete absence of DPEP1 in urine proteome of FSGS subjects compared with healthy and disease controls.

DPEP1 acts via leukotrienes on TRPC6 and results in increased podocyte motility and proteinuria.

Conclusion.

The results suggest a panel of candidate biomarkers for noninvasive diagnosis of FSGS, while complete absence of DPEP1 might represent a novel marker of FSGS.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nafar, Mohsen& Kalantari, Shiva& Samavat, Shiva& Rezaei-Tavirani, Mostafa& Rutishuser, Dorothea& Zubarev, Roman A.. 2014. The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481944

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nafar, Mohsen…[et al.]. The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis. International Journal of Nephrology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481944

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nafar, Mohsen& Kalantari, Shiva& Samavat, Shiva& Rezaei-Tavirani, Mostafa& Rutishuser, Dorothea& Zubarev, Roman A.. The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481944

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-481944