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The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis
Joint Authors
Samavat, Shiva
Kalantari, Shiva
Zubarev, Roman A.
Rezaei-Tavirani, Mostafa
Rutishuser, Dorothea
Nafar, Mohsen
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Focal segmental glomerulosclerosis (FSGS) is a glomerular injury with various pathogenic mechanisms.
Urine proteome panel might help in noninvasive diagnosis and better understanding of pathogenesis of FSGS.
Method.
We have analyzed the urine sample of 11 biopsy-proven FSGS subjects, 8 healthy controls, and 6 patients with biopsy-proven IgA nephropathy (disease controls) by means of liquid chromatography tandem mass spectrometry (nLC-MS/MS).
Multivariate analysis of quantified proteins was performed by principal component analysis (PCA) and partial least squares (PLS).
Results.
Of the total number of 389 proteins, after multivariate analysis and additional filter criterion and comparing FSGS versus IgA nephropathy and healthy subjects, 77 proteins were considered as putative biomarkers of FSGS.
CD59, CD44, IBP7, Robo4, and DPEP1 were the most significant differentially expressed proteins.
These proteins are involved in pathogenic pathways: complement pathway, sclerosis, cell proliferation, actin cytoskeleton remodeling, and activity of TRPC6.There was complete absence of DPEP1 in urine proteome of FSGS subjects compared with healthy and disease controls.
DPEP1 acts via leukotrienes on TRPC6 and results in increased podocyte motility and proteinuria.
Conclusion.
The results suggest a panel of candidate biomarkers for noninvasive diagnosis of FSGS, while complete absence of DPEP1 might represent a novel marker of FSGS.
American Psychological Association (APA)
Nafar, Mohsen& Kalantari, Shiva& Samavat, Shiva& Rezaei-Tavirani, Mostafa& Rutishuser, Dorothea& Zubarev, Roman A.. 2014. The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481944
Modern Language Association (MLA)
Nafar, Mohsen…[et al.]. The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis. International Journal of Nephrology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481944
American Medical Association (AMA)
Nafar, Mohsen& Kalantari, Shiva& Samavat, Shiva& Rezaei-Tavirani, Mostafa& Rutishuser, Dorothea& Zubarev, Roman A.. The Novel Diagnostic Biomarkers for Focal Segmental Glomerulosclerosis. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481944