Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma
المؤلفون المشاركون
Tung, Chun-Liang
Hsieh, Hsiao-Yen
Su, Chih-Ming
Shen, Cheng-Huang
Hsu, Cheng-Da
Chen, Hsin-An
Wang, Yuan-Hung
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Survivin is a member of the inhibitors of apoptosis protein family that plays an important role in carcinogenesis.
Here, we examined the association between survivin expression and clinical outcome in urothelial carcinoma of the bladder (UCB).
Methods.
A total of 56 histopathologically confirmed UCB patients were recruited from the Department of Urology of Chiayi Christian Hospital from August 2007 to May 2009.
Immunohistochemistry (IHC) was used to detect the survivin expression in tumor tissues.
The –31 C/G polymorphism in survivin promoter region was determined by polymerase chain reaction-restricted fragment length polymorphism.
Results.
The frequency of high survivin expression was significantly higher in muscle-invasive tumors (66.6%) than in non-muscle-invasive tumors (34.2%) (P=0.042) and in poorly differentiated (85.7%) tumors than in moderately differentiated tumors (30.8%) (P=0.0014).
The higher frequency of risk genotypes (C/C and C/G) was found in the median (72.7%) and high (68.0%) survivin expression groups.
The multivariate analysis showed that a high survivin expression level was a potential predictive biomarker of poor overall survival (P=0.02).
Conclusion.
Our results suggest that the high survivin expression was associated with tumor stage and grade and may present a predictive marker of overall survival in UCB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Hsin-An& Su, Chih-Ming& Hsieh, Hsiao-Yen& Tung, Chun-Liang& Hsu, Cheng-Da& Wang, Yuan-Hung…[et al.]. 2014. Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482001
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Hsin-An…[et al.]. Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-482001
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Hsin-An& Su, Chih-Ming& Hsieh, Hsiao-Yen& Tung, Chun-Liang& Hsu, Cheng-Da& Wang, Yuan-Hung…[et al.]. Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482001
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482001
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر