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Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma
Joint Authors
Tung, Chun-Liang
Hsieh, Hsiao-Yen
Su, Chih-Ming
Shen, Cheng-Huang
Hsu, Cheng-Da
Chen, Hsin-An
Wang, Yuan-Hung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Survivin is a member of the inhibitors of apoptosis protein family that plays an important role in carcinogenesis.
Here, we examined the association between survivin expression and clinical outcome in urothelial carcinoma of the bladder (UCB).
Methods.
A total of 56 histopathologically confirmed UCB patients were recruited from the Department of Urology of Chiayi Christian Hospital from August 2007 to May 2009.
Immunohistochemistry (IHC) was used to detect the survivin expression in tumor tissues.
The –31 C/G polymorphism in survivin promoter region was determined by polymerase chain reaction-restricted fragment length polymorphism.
Results.
The frequency of high survivin expression was significantly higher in muscle-invasive tumors (66.6%) than in non-muscle-invasive tumors (34.2%) (P=0.042) and in poorly differentiated (85.7%) tumors than in moderately differentiated tumors (30.8%) (P=0.0014).
The higher frequency of risk genotypes (C/C and C/G) was found in the median (72.7%) and high (68.0%) survivin expression groups.
The multivariate analysis showed that a high survivin expression level was a potential predictive biomarker of poor overall survival (P=0.02).
Conclusion.
Our results suggest that the high survivin expression was associated with tumor stage and grade and may present a predictive marker of overall survival in UCB.
American Psychological Association (APA)
Chen, Hsin-An& Su, Chih-Ming& Hsieh, Hsiao-Yen& Tung, Chun-Liang& Hsu, Cheng-Da& Wang, Yuan-Hung…[et al.]. 2014. Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482001
Modern Language Association (MLA)
Chen, Hsin-An…[et al.]. Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-482001
American Medical Association (AMA)
Chen, Hsin-An& Su, Chih-Ming& Hsieh, Hsiao-Yen& Tung, Chun-Liang& Hsu, Cheng-Da& Wang, Yuan-Hung…[et al.]. Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482001