Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer

الملخص EN

Tannic acid is a polyphenolic compound that could be labeled with technetium-99m.

To produce about 90% yield of 99mTc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate.

99mTc-tannic was stable for 6 h.

Oral biodistribution of 99mTc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration.

This concentration of 99mTc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.