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Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction
المؤلفون المشاركون
Harding, Joseph W.
Wright, John W.
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-02-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of synaptic connections (i.e., neural plasticity) by degrading cell adhesion molecules (CAMs) designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia.
It is presumed that while these ECM proteins are weakened, and/or detached, synaptic connections can form resulting in new neural pathways.
Tissue inhibitors of metalloproteinases (TIMPs) are designed to deactivate MMPs permitting the reestablishment of CAMs, thus returning the system to a reasonably fixed state.
This review considers available findings concerning the roles of MMPs and TIMPs in reorganizing ECM proteins thus facilitating the neural plasticity underlying long-term potentiation (LTP), habituation, and associative learning.
We conclude with a consideration of the influence of these phenomena on drug addiction, given that these same processes may be instrumental in the formation of addiction and subsequent relapse.
However, our knowledge concerning the precise spatial and temporal relationships among the mechanisms of neural plasticity, habituation, associative learning, and memory consolidation is far from complete and the possibility that these phenomena mediate drug addiction is a new direction of research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wright, John W.& Harding, Joseph W.. 2010. Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction. Neural Plasticity،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-482312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wright, John W.& Harding, Joseph W.. Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction. Neural Plasticity No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-482312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wright, John W.& Harding, Joseph W.. Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction. Neural Plasticity. 2010. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-482312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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