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Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction
Joint Authors
Harding, Joseph W.
Wright, John W.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of synaptic connections (i.e., neural plasticity) by degrading cell adhesion molecules (CAMs) designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia.
It is presumed that while these ECM proteins are weakened, and/or detached, synaptic connections can form resulting in new neural pathways.
Tissue inhibitors of metalloproteinases (TIMPs) are designed to deactivate MMPs permitting the reestablishment of CAMs, thus returning the system to a reasonably fixed state.
This review considers available findings concerning the roles of MMPs and TIMPs in reorganizing ECM proteins thus facilitating the neural plasticity underlying long-term potentiation (LTP), habituation, and associative learning.
We conclude with a consideration of the influence of these phenomena on drug addiction, given that these same processes may be instrumental in the formation of addiction and subsequent relapse.
However, our knowledge concerning the precise spatial and temporal relationships among the mechanisms of neural plasticity, habituation, associative learning, and memory consolidation is far from complete and the possibility that these phenomena mediate drug addiction is a new direction of research.
American Psychological Association (APA)
Wright, John W.& Harding, Joseph W.. 2010. Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction. Neural Plasticity،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-482312
Modern Language Association (MLA)
Wright, John W.& Harding, Joseph W.. Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction. Neural Plasticity No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-482312
American Medical Association (AMA)
Wright, John W.& Harding, Joseph W.. Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction. Neural Plasticity. 2010. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-482312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482312