Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo
المؤلفون المشاركون
Chuang, Cheng-Hung
Yeh, Shu-Lan
Liao, Jiunn-Wang
Lin, Yi-Chin
Shiau, Rong-Jen
Chan, Shu-Ting
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Our previous study showed that quercetin enhances the anticancer effect of trichostatin A (TSA) in xenograft mice given quercetin intraperitoneally (10 mg/kg, 3 times/week).
Herein, we investigate whether quercetin administered orally exerts such an effect and prevents the cytotoxic side effects of TSA.
We found that quercetin given orally (20 and 100 mg/kg, 3 times/week) failed to enhance the antitumor effect of TSA although it increased the total quercetin concentration more than quercetin administered intraperitoneally in the plasma.
The compound quercetin-3-glucuronide (Q3G) increased the most.
However, quercetin administered intraperitoneally increased the total quercetin level in tumor tissues more than oral quercetin.
Oral and intraperitoneal administration of quercetin similarly decreased lymphocyte DNA damage and plasma lipid peroxidation level induced by TSA.
Furthermore, we found that the enhancing effect of Q3G on the antitumor effect of TSA and the incorporation of Q3G was less than that of quercetin in A549 cells.
However, we found that A549 cells possessed the ability to convert Q3G to quercetin.
In conclusion, different from quercetin administered intraperitoneally, quercetin administered orally failed to enhance the antitumor effect of TSA because of its metabolic conversion.
However, it prevented TSA-induced DNA damage and lipid peroxidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chan, Shu-Ting& Lin, Yi-Chin& Chuang, Cheng-Hung& Shiau, Rong-Jen& Liao, Jiunn-Wang& Yeh, Shu-Lan. 2014. Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-482414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chan, Shu-Ting…[et al.]. Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-482414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chan, Shu-Ting& Lin, Yi-Chin& Chuang, Cheng-Hung& Shiau, Rong-Jen& Liao, Jiunn-Wang& Yeh, Shu-Lan. Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-482414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر