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Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo
Joint Authors
Chuang, Cheng-Hung
Yeh, Shu-Lan
Liao, Jiunn-Wang
Lin, Yi-Chin
Shiau, Rong-Jen
Chan, Shu-Ting
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Our previous study showed that quercetin enhances the anticancer effect of trichostatin A (TSA) in xenograft mice given quercetin intraperitoneally (10 mg/kg, 3 times/week).
Herein, we investigate whether quercetin administered orally exerts such an effect and prevents the cytotoxic side effects of TSA.
We found that quercetin given orally (20 and 100 mg/kg, 3 times/week) failed to enhance the antitumor effect of TSA although it increased the total quercetin concentration more than quercetin administered intraperitoneally in the plasma.
The compound quercetin-3-glucuronide (Q3G) increased the most.
However, quercetin administered intraperitoneally increased the total quercetin level in tumor tissues more than oral quercetin.
Oral and intraperitoneal administration of quercetin similarly decreased lymphocyte DNA damage and plasma lipid peroxidation level induced by TSA.
Furthermore, we found that the enhancing effect of Q3G on the antitumor effect of TSA and the incorporation of Q3G was less than that of quercetin in A549 cells.
However, we found that A549 cells possessed the ability to convert Q3G to quercetin.
In conclusion, different from quercetin administered intraperitoneally, quercetin administered orally failed to enhance the antitumor effect of TSA because of its metabolic conversion.
However, it prevented TSA-induced DNA damage and lipid peroxidation.
American Psychological Association (APA)
Chan, Shu-Ting& Lin, Yi-Chin& Chuang, Cheng-Hung& Shiau, Rong-Jen& Liao, Jiunn-Wang& Yeh, Shu-Lan. 2014. Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-482414
Modern Language Association (MLA)
Chan, Shu-Ting…[et al.]. Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-482414
American Medical Association (AMA)
Chan, Shu-Ting& Lin, Yi-Chin& Chuang, Cheng-Hung& Shiau, Rong-Jen& Liao, Jiunn-Wang& Yeh, Shu-Lan. Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-482414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482414