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N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study
المؤلفون المشاركون
Fernandes, Fernanda B.
Aragão, Danielle S.
Krieger, José Eduardo
Maluf-Meiken, Leila C. V.
Mill, José Geraldo
Ronchi, Fernanda A.
Febba, Andreia C. S.
Sesso, Ricardo C. C.
Plavnik, Frida L.
Andrade, Maria C. C.
Franco, Maria C. P.
Casarini, Dulce Elena
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension.
Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n=1150) and the blood pressure (BP) was measured.
The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n=795), ACE 90+ (65/90) (n=186), and ACE 90− (65/190) (n=169) based on the presence (+) or absence (−) of the 90 kDa ACE isoform.
The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90+ compared with the ACE 90− and ACE 65/90/190 individuals.
We found that 98% of individuals from the ACE 90+ group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90− group.
There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population.
The percentile of normotensive subjects with three isoforms was 62%.
Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maluf-Meiken, Leila C. V.& Fernandes, Fernanda B.& Aragão, Danielle S.& Ronchi, Fernanda A.& Andrade, Maria C. C.& Franco, Maria C. P.…[et al.]. 2012. N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482535
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maluf-Meiken, Leila C. V.…[et al.]. N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study. International Journal of Hypertension No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482535
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maluf-Meiken, Leila C. V.& Fernandes, Fernanda B.& Aragão, Danielle S.& Ronchi, Fernanda A.& Andrade, Maria C. C.& Franco, Maria C. P.…[et al.]. N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482535
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482535
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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