N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study
Joint Authors
Fernandes, Fernanda B.
Aragão, Danielle S.
Krieger, José Eduardo
Maluf-Meiken, Leila C. V.
Mill, José Geraldo
Ronchi, Fernanda A.
Febba, Andreia C. S.
Sesso, Ricardo C. C.
Plavnik, Frida L.
Andrade, Maria C. C.
Franco, Maria C. P.
Casarini, Dulce Elena
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension.
Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n=1150) and the blood pressure (BP) was measured.
The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n=795), ACE 90+ (65/90) (n=186), and ACE 90− (65/190) (n=169) based on the presence (+) or absence (−) of the 90 kDa ACE isoform.
The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90+ compared with the ACE 90− and ACE 65/90/190 individuals.
We found that 98% of individuals from the ACE 90+ group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90− group.
There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population.
The percentile of normotensive subjects with three isoforms was 62%.
Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease.
American Psychological Association (APA)
Maluf-Meiken, Leila C. V.& Fernandes, Fernanda B.& Aragão, Danielle S.& Ronchi, Fernanda A.& Andrade, Maria C. C.& Franco, Maria C. P.…[et al.]. 2012. N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482535
Modern Language Association (MLA)
Maluf-Meiken, Leila C. V.…[et al.]. N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study. International Journal of Hypertension No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482535
American Medical Association (AMA)
Maluf-Meiken, Leila C. V.& Fernandes, Fernanda B.& Aragão, Danielle S.& Ronchi, Fernanda A.& Andrade, Maria C. C.& Franco, Maria C. P.…[et al.]. N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension : Populational Study. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482535