A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ
المؤلفون المشاركون
Jirström, Karin
Fjallskog, Marie-Louise
Wärnberg, Fredrik
Blomqvist, Carl
Ringberg, Anita
Amini, Rose-Marie
Zhou, Wenjing
Johansson, Christine
المصدر
International Journal of Breast Cancer
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
About half of all new ipsilateral events after a primary ductal carcinoma in situ (DCIS) are invasive carcinoma.
We studied tumor markers in the primary DCIS in relation to type of event (invasive versus in situ).
Methods.
Two hundred and sixty-six women with a primary DCIS from two source populations, all with a known ipsilateral event, were included.
All new events were regarded as recurrences.
Patient and primary tumor characteristics (estrogen receptor (ER), progesterone receptor (PR), HER2, EGFR, and Ki67) were evaluated.
Logistic regression was used to calculate odd ratios and 95% confidence intervals in univariate and multivariate analyses.
Results.
One hundred and thirty-six of the recurrences were invasive carcinoma and 130 were in situ.
The recurrence was more often invasive if the primary DCIS was ER+ (OR 2.5, 95% CI 1.2–5.1).
Primary DCIS being HER2+ (OR 0.5, 95% CI 0.3–0.9), EGFR+ (OR 0.4, 95% CI 0.2–0.9), and ER95−/HER2+ (OR 0.2, 95% CI 0.1–0.6) had a lower risk of a recurrence being invasive.
Conclusions.
In this study, comparing type of recurrence after a DCIS showed that the ER−/HER2+ tumors were related to a recurrence being a new DCIS.
And surprisingly, tumors being ER+, HER2−, and EGFR− were related to a recurrence being invasive cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Wenjing& Johansson, Christine& Jirström, Karin& Ringberg, Anita& Blomqvist, Carl& Amini, Rose-Marie…[et al.]. 2013. A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482568
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Wenjing…[et al.]. A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ. International Journal of Breast Cancer No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-482568
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Wenjing& Johansson, Christine& Jirström, Karin& Ringberg, Anita& Blomqvist, Carl& Amini, Rose-Marie…[et al.]. A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482568
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482568
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر