A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ
Joint Authors
Jirström, Karin
Fjallskog, Marie-Louise
Wärnberg, Fredrik
Blomqvist, Carl
Ringberg, Anita
Amini, Rose-Marie
Zhou, Wenjing
Johansson, Christine
Source
International Journal of Breast Cancer
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
About half of all new ipsilateral events after a primary ductal carcinoma in situ (DCIS) are invasive carcinoma.
We studied tumor markers in the primary DCIS in relation to type of event (invasive versus in situ).
Methods.
Two hundred and sixty-six women with a primary DCIS from two source populations, all with a known ipsilateral event, were included.
All new events were regarded as recurrences.
Patient and primary tumor characteristics (estrogen receptor (ER), progesterone receptor (PR), HER2, EGFR, and Ki67) were evaluated.
Logistic regression was used to calculate odd ratios and 95% confidence intervals in univariate and multivariate analyses.
Results.
One hundred and thirty-six of the recurrences were invasive carcinoma and 130 were in situ.
The recurrence was more often invasive if the primary DCIS was ER+ (OR 2.5, 95% CI 1.2–5.1).
Primary DCIS being HER2+ (OR 0.5, 95% CI 0.3–0.9), EGFR+ (OR 0.4, 95% CI 0.2–0.9), and ER95−/HER2+ (OR 0.2, 95% CI 0.1–0.6) had a lower risk of a recurrence being invasive.
Conclusions.
In this study, comparing type of recurrence after a DCIS showed that the ER−/HER2+ tumors were related to a recurrence being a new DCIS.
And surprisingly, tumors being ER+, HER2−, and EGFR− were related to a recurrence being invasive cancer.
American Psychological Association (APA)
Zhou, Wenjing& Johansson, Christine& Jirström, Karin& Ringberg, Anita& Blomqvist, Carl& Amini, Rose-Marie…[et al.]. 2013. A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482568
Modern Language Association (MLA)
Zhou, Wenjing…[et al.]. A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ. International Journal of Breast Cancer No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-482568
American Medical Association (AMA)
Zhou, Wenjing& Johansson, Christine& Jirström, Karin& Ringberg, Anita& Blomqvist, Carl& Amini, Rose-Marie…[et al.]. A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482568