Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study
المؤلفون المشاركون
Light, K. C.
Tadler, Scott
Weeks, H. R.
Hughen, R. W.
Smith, K. W.
VanHaitsma, T. A.
Iacob, Eli
White, Andrea T.
Light, Alan R.
Bushnell, L. A.
المصدر
Depression Research and Treatment
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate leukocyte gene expression for 9 selected genes (mRNAs) as biological markers in patients with medication refractory depression before and after treatment with ECT or isoflurane anesthesia (ISO).
Methods.
In a substudy of a nonrandomized open-label trial comparing effects of ECT to ISO therapy, blood samples were obtained before and after treatment from 22 patients with refractory depression, and leukocyte mRNA was assessed by quantitative PCR.
Patients’ mRNAs were also compared to 17 healthy controls.
Results.
Relative to controls, patients before treatment showed significantly higher IL10 and DBI and lower ADRA2A and ASIC3 mRNA (P<0.025).
Both ECT and ISO induced significant decreases after treatment in 4 genes: IL10, NR3C1, DRD4, and Sult1A1.
After treatment, patients’ DBI, ASIC3, and ADRA2A mRNA remained dysregulated.
Conclusion.
Significant differences from controls and/or significant changes after ECT or ISO treatment were observed for 7 of the 9 mRNAs studied.
Decreased expression of 4 genes after effective treatment with either ECT or ISO suggests possible overlap of underlying mechanisms.
Three genes showing dysregulation before and after treatment may be trait-like biomarkers of medication refractory depression.
Gene expression for these patients has the potential to facilitate diagnosis, clarify pathophysiology, and identify potential biomarkers for treatment effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iacob, Eli& Tadler, Scott& Light, K. C.& Weeks, H. R.& Smith, K. W.& White, Andrea T.…[et al.]. 2014. Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study. Depression Research and Treatment،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-482581
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iacob, Eli…[et al.]. Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study. Depression Research and Treatment No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-482581
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iacob, Eli& Tadler, Scott& Light, K. C.& Weeks, H. R.& Smith, K. W.& White, Andrea T.…[et al.]. Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study. Depression Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-482581
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482581
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر