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Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study
Joint Authors
Light, K. C.
Tadler, Scott
Weeks, H. R.
Hughen, R. W.
Smith, K. W.
VanHaitsma, T. A.
Iacob, Eli
White, Andrea T.
Light, Alan R.
Bushnell, L. A.
Source
Depression Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To evaluate leukocyte gene expression for 9 selected genes (mRNAs) as biological markers in patients with medication refractory depression before and after treatment with ECT or isoflurane anesthesia (ISO).
Methods.
In a substudy of a nonrandomized open-label trial comparing effects of ECT to ISO therapy, blood samples were obtained before and after treatment from 22 patients with refractory depression, and leukocyte mRNA was assessed by quantitative PCR.
Patients’ mRNAs were also compared to 17 healthy controls.
Results.
Relative to controls, patients before treatment showed significantly higher IL10 and DBI and lower ADRA2A and ASIC3 mRNA (P<0.025).
Both ECT and ISO induced significant decreases after treatment in 4 genes: IL10, NR3C1, DRD4, and Sult1A1.
After treatment, patients’ DBI, ASIC3, and ADRA2A mRNA remained dysregulated.
Conclusion.
Significant differences from controls and/or significant changes after ECT or ISO treatment were observed for 7 of the 9 mRNAs studied.
Decreased expression of 4 genes after effective treatment with either ECT or ISO suggests possible overlap of underlying mechanisms.
Three genes showing dysregulation before and after treatment may be trait-like biomarkers of medication refractory depression.
Gene expression for these patients has the potential to facilitate diagnosis, clarify pathophysiology, and identify potential biomarkers for treatment effects.
American Psychological Association (APA)
Iacob, Eli& Tadler, Scott& Light, K. C.& Weeks, H. R.& Smith, K. W.& White, Andrea T.…[et al.]. 2014. Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study. Depression Research and Treatment،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-482581
Modern Language Association (MLA)
Iacob, Eli…[et al.]. Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study. Depression Research and Treatment No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-482581
American Medical Association (AMA)
Iacob, Eli& Tadler, Scott& Light, K. C.& Weeks, H. R.& Smith, K. W.& White, Andrea T.…[et al.]. Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia : A Pilot Study. Depression Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-482581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482581