POEMS Syndrome : A Report of 14 Cases and Review of the Literature
المؤلفون المشاركون
Zhang, Dan Ying
Dong, Ling
Ji, Zong Fei
Weng, Shu Qiang
Shen, Xi Zhong
Liu, Hou Yu
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
POEMS syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia presenting polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes.
This study reviewed the clinical characteristics of 14 POEMS patients in Zhongshan hospital.
The ratio of male to female was 9 : 5, and the average age was 47.1 years.
The clinical manifestations were various, including motorial symptoms (weakness), sensory symptoms (numbness), lymphadenopathy, edema, abdominal distention, and skin hyperpigmentation.
Imaging studies and laboratory tests also exhibited hepatomegaly, splenomegaly, thrombocytosis, endocrinopathy, and positive serum immunofixation in most patients.
In addition, increased plasma cells in bone marrow and Castleman Disease were found in bone marrow and lymph nodes biopsies.
All the eight follow-up patients were treated with alkylator-based combination chemotherapy or corticosteroids and thalidomide, with or without autologous stem cell transplantation.
Unfortunately, two patients died three or four years after diagnosis of POEMS syndrome.
The others showed response to therapy to some extent, but not completely remission.
Currently, treatments for POEMS include radiation to the plasmacytoma, and systemic therapy is indicated.
Low-dose alkylators with or without corticosteroids are effective in some patients.
However, high-dose chemotherapy with auto-SCT dramatically improved symptoms and outcomes for POEMS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ji, Zong Fei& Zhang, Dan Ying& Weng, Shu Qiang& Shen, Xi Zhong& Liu, Hou Yu& Dong, Ling. 2012. POEMS Syndrome : A Report of 14 Cases and Review of the Literature. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ji, Zong Fei…[et al.]. POEMS Syndrome : A Report of 14 Cases and Review of the Literature. ISRN Gastroenterology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-482753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ji, Zong Fei& Zhang, Dan Ying& Weng, Shu Qiang& Shen, Xi Zhong& Liu, Hou Yu& Dong, Ling. POEMS Syndrome : A Report of 14 Cases and Review of the Literature. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر