POEMS Syndrome : A Report of 14 Cases and Review of the Literature
Joint Authors
Zhang, Dan Ying
Dong, Ling
Ji, Zong Fei
Weng, Shu Qiang
Shen, Xi Zhong
Liu, Hou Yu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
POEMS syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia presenting polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes.
This study reviewed the clinical characteristics of 14 POEMS patients in Zhongshan hospital.
The ratio of male to female was 9 : 5, and the average age was 47.1 years.
The clinical manifestations were various, including motorial symptoms (weakness), sensory symptoms (numbness), lymphadenopathy, edema, abdominal distention, and skin hyperpigmentation.
Imaging studies and laboratory tests also exhibited hepatomegaly, splenomegaly, thrombocytosis, endocrinopathy, and positive serum immunofixation in most patients.
In addition, increased plasma cells in bone marrow and Castleman Disease were found in bone marrow and lymph nodes biopsies.
All the eight follow-up patients were treated with alkylator-based combination chemotherapy or corticosteroids and thalidomide, with or without autologous stem cell transplantation.
Unfortunately, two patients died three or four years after diagnosis of POEMS syndrome.
The others showed response to therapy to some extent, but not completely remission.
Currently, treatments for POEMS include radiation to the plasmacytoma, and systemic therapy is indicated.
Low-dose alkylators with or without corticosteroids are effective in some patients.
However, high-dose chemotherapy with auto-SCT dramatically improved symptoms and outcomes for POEMS patients.
American Psychological Association (APA)
Ji, Zong Fei& Zhang, Dan Ying& Weng, Shu Qiang& Shen, Xi Zhong& Liu, Hou Yu& Dong, Ling. 2012. POEMS Syndrome : A Report of 14 Cases and Review of the Literature. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482753
Modern Language Association (MLA)
Ji, Zong Fei…[et al.]. POEMS Syndrome : A Report of 14 Cases and Review of the Literature. ISRN Gastroenterology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-482753
American Medical Association (AMA)
Ji, Zong Fei& Zhang, Dan Ying& Weng, Shu Qiang& Shen, Xi Zhong& Liu, Hou Yu& Dong, Ling. POEMS Syndrome : A Report of 14 Cases and Review of the Literature. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482753