Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
المؤلفون المشاركون
Estrada-Capetillo, Lizbeth
Layseca-Espinosa, Esther
Sánchez-Madrid, Francisco
Urzainqui, Ana
Monsiváis-Urenda, Adriana
González-Amaro, Roberto
Abud-Mendoza, Carlos
Alvarez-Quiroga, Crisol
Hernández-Castro, Berenice
Baranda, Lourdes
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Dendritic cells (DCs) have a key role in the regulation of immune response.
We herein explored, in patients with inflammatory diseases, the role of monocyte derived DC’s (mo-DCs) on the generation of Th17 and T regulatory (Treg) lymphocytes.
Peripheral blood was obtained from thirty-five patients with rheumatoid arthritis (RA), twelve with systemic lupus erythematosus (SLE), and twenty healthy subjects.
Mo-DCs were generated under standard (IL-4/GM-CSF) or tolerogenic (IL-4/GM-CSF plus recombinant P-selectin or PD-1 or IL-10) conditions, and their ability to induce Th17 and Treg lymphocytes was tested.
We detected that mo-DCs from patients with RA showed an enhanced release of IL-6 and IL-23 as well as an increased capability to induce Th17 cells.
Although mo-DCs from SLE patients also released high levels of IL-6/IL-23, it did not show an increased ability to induce Th17 lymphocytes.
In addition, mo-DCs, from patients with RA and SLE generated under the engagement of PSGL-1, showed a defective capability to induce Foxp3+ Treg cells.
A similar phenomenon was observed in SLE, when DC’s cells were generated under PDL-1 engagement.
Our data indicate that DCs from patients with rheumatic inflammatory disease show an aberrant function that may have an important role in the pathogenesis of these conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Estrada-Capetillo, Lizbeth& Hernández-Castro, Berenice& Monsiváis-Urenda, Adriana& Alvarez-Quiroga, Crisol& Layseca-Espinosa, Esther& Abud-Mendoza, Carlos…[et al.]. 2013. Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-482755
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Estrada-Capetillo, Lizbeth…[et al.]. Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-482755
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Estrada-Capetillo, Lizbeth& Hernández-Castro, Berenice& Monsiváis-Urenda, Adriana& Alvarez-Quiroga, Crisol& Layseca-Espinosa, Esther& Abud-Mendoza, Carlos…[et al.]. Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-482755
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482755
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر