Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Joint Authors
Estrada-Capetillo, Lizbeth
Layseca-Espinosa, Esther
Sánchez-Madrid, Francisco
Urzainqui, Ana
Monsiváis-Urenda, Adriana
González-Amaro, Roberto
Abud-Mendoza, Carlos
Alvarez-Quiroga, Crisol
Hernández-Castro, Berenice
Baranda, Lourdes
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dendritic cells (DCs) have a key role in the regulation of immune response.
We herein explored, in patients with inflammatory diseases, the role of monocyte derived DC’s (mo-DCs) on the generation of Th17 and T regulatory (Treg) lymphocytes.
Peripheral blood was obtained from thirty-five patients with rheumatoid arthritis (RA), twelve with systemic lupus erythematosus (SLE), and twenty healthy subjects.
Mo-DCs were generated under standard (IL-4/GM-CSF) or tolerogenic (IL-4/GM-CSF plus recombinant P-selectin or PD-1 or IL-10) conditions, and their ability to induce Th17 and Treg lymphocytes was tested.
We detected that mo-DCs from patients with RA showed an enhanced release of IL-6 and IL-23 as well as an increased capability to induce Th17 cells.
Although mo-DCs from SLE patients also released high levels of IL-6/IL-23, it did not show an increased ability to induce Th17 lymphocytes.
In addition, mo-DCs, from patients with RA and SLE generated under the engagement of PSGL-1, showed a defective capability to induce Foxp3+ Treg cells.
A similar phenomenon was observed in SLE, when DC’s cells were generated under PDL-1 engagement.
Our data indicate that DCs from patients with rheumatic inflammatory disease show an aberrant function that may have an important role in the pathogenesis of these conditions.
American Psychological Association (APA)
Estrada-Capetillo, Lizbeth& Hernández-Castro, Berenice& Monsiváis-Urenda, Adriana& Alvarez-Quiroga, Crisol& Layseca-Espinosa, Esther& Abud-Mendoza, Carlos…[et al.]. 2013. Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-482755
Modern Language Association (MLA)
Estrada-Capetillo, Lizbeth…[et al.]. Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-482755
American Medical Association (AMA)
Estrada-Capetillo, Lizbeth& Hernández-Castro, Berenice& Monsiváis-Urenda, Adriana& Alvarez-Quiroga, Crisol& Layseca-Espinosa, Esther& Abud-Mendoza, Carlos…[et al.]. Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-482755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482755