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Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats
المؤلفون المشاركون
Patel, Urvesh D.
Patel, Vipul A.
Patel, Harshad B.
Mody, Shailesh K.
Patel, Hitesh B.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats.
Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC).
After i.v.
administration, distribution of the drug was rapid and wide as reflected by high steady-state volume of distribution.
Drug elimination was relatively faster with a total body clearance of 0.59±0.03 L/h/kg.
Following i.m.
injection, the drug has shown the rapid and near-to-complete absorption with bioavailability of 98.20±3.96 per cent.
The maximum plasma drug concentration (Cmax) of 1.21±0.04 μg/mL was attained at 1 h (Tmax).
The drug was widely distributed as reflected by high apparent volume of distribution.
The elimination half-life (t1/2β) of the drug was 6.26±0.08 h.
Following s.c.
administration, the drug was rapidly absorbed (Cmax: 1.16±0.02 μg/mL; tmax: 1 h) and slowly eliminated from the body.
The elimination half-life and total body clearance (ClB) were 5.61±0.10 h and 0.60±0.03 L/h/kg, respectively.
The bioavailability of moxifloxacin following s.c.
administration was 90.44±3.96 per cent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patel, Harshad B.& Mody, Shailesh K.& Patel, Hitesh B.& Patel, Vipul A.& Patel, Urvesh D.. 2011. Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats. ISRN Veterinary Science،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-482758
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patel, Harshad B.…[et al.]. Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats. ISRN Veterinary Science No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-482758
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patel, Harshad B.& Mody, Shailesh K.& Patel, Hitesh B.& Patel, Vipul A.& Patel, Urvesh D.. Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats. ISRN Veterinary Science. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-482758
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482758
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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