Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats

Abstract EN

The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats.

Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC).

After i.v.

administration, distribution of the drug was rapid and wide as reflected by high steady-state volume of distribution.

Drug elimination was relatively faster with a total body clearance of 0.59±0.03 L/h/kg.

Following i.m.

injection, the drug has shown the rapid and near-to-complete absorption with bioavailability of 98.20±3.96 per cent.

The maximum plasma drug concentration (Cmax) of 1.21±0.04 μg/mL was attained at 1 h (Tmax).

The drug was widely distributed as reflected by high apparent volume of distribution.

The elimination half-life (t1/2β) of the drug was 6.26±0.08 h.

Following s.c.

administration, the drug was rapidly absorbed (Cmax: 1.16±0.02 μg/mL; tmax: 1 h) and slowly eliminated from the body.

The elimination half-life and total body clearance (ClB) were 5.61±0.10 h and 0.60±0.03 L/h/kg, respectively.

The bioavailability of moxifloxacin following s.c.

administration was 90.44±3.96 per cent.