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Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction
المؤلفون المشاركون
Griscti, O.
Mizier-Barre, K. A.
Muthuthevar, D.
Hobson, J.
Barre, D. E.
Stelmach, E.
Rudiuk, A.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
Animal and human study evidence supports the hypothesis that flaxseed lignan complex (FLC) at a dose of 600 mg secoisolariciresinol diglucoside (SDG)/day for three months would combat hyperglycaemia, dyslipidemia, blood pressure, central obesity, prothrombotic state, inflammation, and low density lipoprotein (LDL) oxidation.
Methods.
Sixteen type 2 diabetic patients completed this double-blind, randomised crossover placebo-controlled study.
A univariate repeated measures analysis of covariance (significance P<0.05) was followed by a mixed linear model effects analysis corrected for multiple comparisons (MCC).
Results.
Prior to MCC, FLC caused decreased fasting plasma glucose, A1c, inflammation (c-reactive protein (CRP) and interleukin-6 (IL-6)), and increased bleeding time.
After correction for multiple comparisons, FLC induced a statistically significant increase in bleeding time and smaller waist circumference gain.
No treatment effect occurred in the other variables before or after adjustment.
Conclusions.
It is concluded that FLC significantly increased bleeding time thus reducing the prothrombotic state, reduced central obesity gain as measured by waist circumference, and did not affect significantly the other dependent variables measured after adjustment for multiple comparisons.
These findings, not yet published in human type 2 diabetes, suggest that this FLC dose over at least three months, may, subject to further investigation, reduce polypharmacy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barre, D. E.& Mizier-Barre, K. A.& Stelmach, E.& Hobson, J.& Griscti, O.& Rudiuk, A.…[et al.]. 2012. Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-482837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barre, D. E.…[et al.]. Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-482837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barre, D. E.& Mizier-Barre, K. A.& Stelmach, E.& Hobson, J.& Griscti, O.& Rudiuk, A.…[et al.]. Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-482837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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