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Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate
المؤلفون المشاركون
Zakarya, Driss
Sebti, Saïd
Rayadh, Ahmed
Abrouki, Younes
Loukili, Hayat
Zahouily, Mohamed
Lotfi, Rabiaâ
Bahlaoui, My Abdellah
Anouzla, Abdelkader
Bennazha, Jamal
المصدر
International Journal of Medicinal Chemistry
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
A simple protocol for the efficient preparation of β-mercapto carbonyl derivatives as antimycobacterial drugs has been achieved via Thia-Michael reaction between chalcones derivatives and thiols in the presence of calcium pyrophosphate as a heterogeneous catalyst under mild reaction conditions.
The central composite design was used to design an experimental program to provide data to model the effects of various factors on reaction yield (Y).
The variables chosen were catalyst weight X1, reaction time X2, and solvent volume X3.
The mathematical relationship of reaction yield on the three significant independent variables can be approximated by a nonlinear polynomial model.
Predicted values were found to be in good agreement with experimental values.
The optimum reaction conditions for reaction model (chalcone and thiophenol) obtained by response surface were applied to other substrates.
This procedure provides several advantages such as high yield, clean product formation, and short reaction time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abrouki, Younes& Anouzla, Abdelkader& Loukili, Hayat& Bennazha, Jamal& Lotfi, Rabiaâ& Rayadh, Ahmed…[et al.]. 2014. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate. International Journal of Medicinal Chemistry،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abrouki, Younes…[et al.]. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate. International Journal of Medicinal Chemistry No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-482949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abrouki, Younes& Anouzla, Abdelkader& Loukili, Hayat& Bennazha, Jamal& Lotfi, Rabiaâ& Rayadh, Ahmed…[et al.]. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate. International Journal of Medicinal Chemistry. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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