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Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate
Joint Authors
Zakarya, Driss
Sebti, Saïd
Rayadh, Ahmed
Abrouki, Younes
Loukili, Hayat
Zahouily, Mohamed
Lotfi, Rabiaâ
Bahlaoui, My Abdellah
Anouzla, Abdelkader
Bennazha, Jamal
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A simple protocol for the efficient preparation of β-mercapto carbonyl derivatives as antimycobacterial drugs has been achieved via Thia-Michael reaction between chalcones derivatives and thiols in the presence of calcium pyrophosphate as a heterogeneous catalyst under mild reaction conditions.
The central composite design was used to design an experimental program to provide data to model the effects of various factors on reaction yield (Y).
The variables chosen were catalyst weight X1, reaction time X2, and solvent volume X3.
The mathematical relationship of reaction yield on the three significant independent variables can be approximated by a nonlinear polynomial model.
Predicted values were found to be in good agreement with experimental values.
The optimum reaction conditions for reaction model (chalcone and thiophenol) obtained by response surface were applied to other substrates.
This procedure provides several advantages such as high yield, clean product formation, and short reaction time.
American Psychological Association (APA)
Abrouki, Younes& Anouzla, Abdelkader& Loukili, Hayat& Bennazha, Jamal& Lotfi, Rabiaâ& Rayadh, Ahmed…[et al.]. 2014. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate. International Journal of Medicinal Chemistry،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482949
Modern Language Association (MLA)
Abrouki, Younes…[et al.]. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate. International Journal of Medicinal Chemistry No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-482949
American Medical Association (AMA)
Abrouki, Younes& Anouzla, Abdelkader& Loukili, Hayat& Bennazha, Jamal& Lotfi, Rabiaâ& Rayadh, Ahmed…[et al.]. Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate. International Journal of Medicinal Chemistry. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482949