Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases

الملخص EN

Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2.

IL-33 exerts its functions via its target cells and plays different roles in diseases.

ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases.

It has been reported that IL-33/ST2 pathway plays a key role in host defense and immune regulation in inflammatory and infectious diseases.

This review focuses on new findings in the roles of IL-33 and ST2 in several kinds of T cell-mediated autoimmune diseases.