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Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
المؤلفون المشاركون
Mathur, Sandeep Kumar
Jain, Priyanka
Mathur, Prashant
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue.
The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation.
However, it's underlying molecular mechanisms remains unknown.
Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy.
Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array.
This technique has several potential applications in understanding pathologic adipose tissue.
They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression.
The microarray evidences of molecular basis of obesity and insulin resistance are presented here.
Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mathur, Sandeep Kumar& Jain, Priyanka& Mathur, Prashant. 2011. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications. Journal of Obesity،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-483052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mathur, Sandeep Kumar…[et al.]. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications. Journal of Obesity No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-483052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mathur, Sandeep Kumar& Jain, Priyanka& Mathur, Prashant. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-483052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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