Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
Joint Authors
Mathur, Sandeep Kumar
Jain, Priyanka
Mathur, Prashant
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue.
The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation.
However, it's underlying molecular mechanisms remains unknown.
Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy.
Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array.
This technique has several potential applications in understanding pathologic adipose tissue.
They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression.
The microarray evidences of molecular basis of obesity and insulin resistance are presented here.
Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome.
American Psychological Association (APA)
Mathur, Sandeep Kumar& Jain, Priyanka& Mathur, Prashant. 2011. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications. Journal of Obesity،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-483052
Modern Language Association (MLA)
Mathur, Sandeep Kumar…[et al.]. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications. Journal of Obesity No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-483052
American Medical Association (AMA)
Mathur, Sandeep Kumar& Jain, Priyanka& Mathur, Prashant. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-483052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483052