Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach
المؤلفون المشاركون
Fuchs, Hans U.
Füchslin, Rudolf M.
Scheidegger, Stephan
Bodis, Stephan
Zaugg, Kathrin
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
In order to overcome the limitations of the linear-quadratic model and include synergistic effects of heat and radiation, a novel radiobiological model is proposed.
The model is based on a chain of cell populations which are characterized by the number of radiation induced damages (hits).
Cells can shift downward along the chain by collecting hits and upward by a repair process.
The repair process is governed by a repair probability which depends upon state variables used for a simplistic description of the impact of heat and radiation upon repair proteins.
Based on the parameters used, populations up to 4-5 hits are relevant for the calculation of the survival.
The model describes intuitively the mathematical behaviour of apoptotic and nonapoptotic cell death.
Linear-quadratic-linear behaviour of the logarithmic cell survival, fractionation, and (with one exception) the dose rate dependencies are described correctly.
The model covers the time gap dependence of the synergistic cell killing due to combined application of heat and radiation, but further validation of the proposed approach based on experimental data is needed.
However, the model offers a work bench for testing different biological concepts of damage induction, repair, and statistical approaches for calculating the variables of state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scheidegger, Stephan& Fuchs, Hans U.& Zaugg, Kathrin& Bodis, Stephan& Füchslin, Rudolf M.. 2013. Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-483058
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scheidegger, Stephan…[et al.]. Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-483058
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scheidegger, Stephan& Fuchs, Hans U.& Zaugg, Kathrin& Bodis, Stephan& Füchslin, Rudolf M.. Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-483058
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483058
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر