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Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach
Joint Authors
Fuchs, Hans U.
Füchslin, Rudolf M.
Scheidegger, Stephan
Bodis, Stephan
Zaugg, Kathrin
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In order to overcome the limitations of the linear-quadratic model and include synergistic effects of heat and radiation, a novel radiobiological model is proposed.
The model is based on a chain of cell populations which are characterized by the number of radiation induced damages (hits).
Cells can shift downward along the chain by collecting hits and upward by a repair process.
The repair process is governed by a repair probability which depends upon state variables used for a simplistic description of the impact of heat and radiation upon repair proteins.
Based on the parameters used, populations up to 4-5 hits are relevant for the calculation of the survival.
The model describes intuitively the mathematical behaviour of apoptotic and nonapoptotic cell death.
Linear-quadratic-linear behaviour of the logarithmic cell survival, fractionation, and (with one exception) the dose rate dependencies are described correctly.
The model covers the time gap dependence of the synergistic cell killing due to combined application of heat and radiation, but further validation of the proposed approach based on experimental data is needed.
However, the model offers a work bench for testing different biological concepts of damage induction, repair, and statistical approaches for calculating the variables of state.
American Psychological Association (APA)
Scheidegger, Stephan& Fuchs, Hans U.& Zaugg, Kathrin& Bodis, Stephan& Füchslin, Rudolf M.. 2013. Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-483058
Modern Language Association (MLA)
Scheidegger, Stephan…[et al.]. Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-483058
American Medical Association (AMA)
Scheidegger, Stephan& Fuchs, Hans U.& Zaugg, Kathrin& Bodis, Stephan& Füchslin, Rudolf M.. Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-483058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483058