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Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats
المؤلفون المشاركون
Shin, Hyeun-Kyoo
Kim, Young-Bum
Shin, In-Shik
Kim, Jung Hoon
Lee, Mee-Young
Seo, Chang-Seob
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Soshiho-tang (Xiao-chai-hu-tang in Chinese and Sho-saiko-to in Japanese) has been widely used for its various pharmacological effects, which include anti-inflammatory, antioxidant, antihepatic fibrosis, and antitumor properties.
To evaluate the safety of Soshiho-tang water extract (SST), we tested its subchronic toxicity in male and female Crl:CD (SD) rats.
Rats were orally treated with four different doses (0, 500, 1000, and 2000 mg/kg/day) of SST administered for 13 weeks.
Mortality, clinical signs, body weight changes, food and water consumption changes, ophthalmology, urinalysis, hematological and biochemical parameters, gross findings, organ weights, and histological markers were monitored during the study.
The SST treatment did not result in any toxicologically significant changes in mortality, clinical signs, body weights, food and water consumption, ophthalmoscopy, urinalysis, hematological and serum biochemical parameters, gross findings, organ weights, or histopathology.
Histological analysis did not show any liver or kidney alteration.
We concluded that the 13-week repeated oral administration of SST did not cause any adverse effects in rats at dosage levels of ≤2000 mg/kg/day.
Under these experimental conditions, the no-observed-adverse-effect level was concluded to be 2000 mg/kg/day for both sexes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Mee-Young& Seo, Chang-Seob& Shin, In-Shik& Kim, Young-Bum& Kim, Jung Hoon& Shin, Hyeun-Kyoo. 2013. Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Mee-Young…[et al.]. Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-483204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Mee-Young& Seo, Chang-Seob& Shin, In-Shik& Kim, Young-Bum& Kim, Jung Hoon& Shin, Hyeun-Kyoo. Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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