Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats
Joint Authors
Shin, Hyeun-Kyoo
Kim, Young-Bum
Shin, In-Shik
Kim, Jung Hoon
Lee, Mee-Young
Seo, Chang-Seob
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Soshiho-tang (Xiao-chai-hu-tang in Chinese and Sho-saiko-to in Japanese) has been widely used for its various pharmacological effects, which include anti-inflammatory, antioxidant, antihepatic fibrosis, and antitumor properties.
To evaluate the safety of Soshiho-tang water extract (SST), we tested its subchronic toxicity in male and female Crl:CD (SD) rats.
Rats were orally treated with four different doses (0, 500, 1000, and 2000 mg/kg/day) of SST administered for 13 weeks.
Mortality, clinical signs, body weight changes, food and water consumption changes, ophthalmology, urinalysis, hematological and biochemical parameters, gross findings, organ weights, and histological markers were monitored during the study.
The SST treatment did not result in any toxicologically significant changes in mortality, clinical signs, body weights, food and water consumption, ophthalmoscopy, urinalysis, hematological and serum biochemical parameters, gross findings, organ weights, or histopathology.
Histological analysis did not show any liver or kidney alteration.
We concluded that the 13-week repeated oral administration of SST did not cause any adverse effects in rats at dosage levels of ≤2000 mg/kg/day.
Under these experimental conditions, the no-observed-adverse-effect level was concluded to be 2000 mg/kg/day for both sexes.
American Psychological Association (APA)
Lee, Mee-Young& Seo, Chang-Seob& Shin, In-Shik& Kim, Young-Bum& Kim, Jung Hoon& Shin, Hyeun-Kyoo. 2013. Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483204
Modern Language Association (MLA)
Lee, Mee-Young…[et al.]. Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-483204
American Medical Association (AMA)
Lee, Mee-Young& Seo, Chang-Seob& Shin, In-Shik& Kim, Young-Bum& Kim, Jung Hoon& Shin, Hyeun-Kyoo. Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract : The Traditional Herbal Formula in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483204