BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis
المؤلفون المشاركون
Campos-Galindo, Inmaculada
Rubio, Carmen
Serra, Vicente
García-Herrero, Sandra
Olmo, Inés
Simón, Carlos
Martínez-Conejero, José Antonio
Lara, Coral
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk.
The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF) or chorionic villus (CV) samples based on BACs-on-Beads (BoBs) technology and to compare the results with classical karyotyping by Giemsa banding (G-banding) of cultured cells in metaphase as the gold standard technique.
The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples.
G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples.
A microarray-based comparative genomic hybridization (aCGH) was also carried out in a subset of samples.
Prenatal-BoBs results were widely confirmed by classical karyotyping.
Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique.
In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
García-Herrero, Sandra& Campos-Galindo, Inmaculada& Martínez-Conejero, José Antonio& Serra, Vicente& Olmo, Inés& Lara, Coral…[et al.]. 2014. BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-483218
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
García-Herrero, Sandra…[et al.]. BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-483218
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
García-Herrero, Sandra& Campos-Galindo, Inmaculada& Martínez-Conejero, José Antonio& Serra, Vicente& Olmo, Inés& Lara, Coral…[et al.]. BACs-on-Beads Technology : A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-483218
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483218
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر