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Quercetin and Cancer Chemoprevention
المؤلفون المشاركون
Nasi, Milena
Bertoncelli, Linda
Gibellini, Lara
Montagna, Jonas P.
De Biasi, Sara
Roat, Erika
Cooper, Edwin L.
Cossarizza, Andrea
Pinti, Marcello
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-14
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Several molecules present in the diet, including flavonoids, can inhibit the growth of cancer cells with an ability to act as “chemopreventers”.
Their cancer-preventive effects have been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis as well as the antioxidant functions.
The antioxidant activity of chemopreventers has recently received a great interest, essentially because oxidative stress participates in the initiation and progression of different pathological conditions, including cancer.
Since antioxidants are capable of preventing oxidative damage, the wide use of natural food-derived antioxidants is receiving greater attention as potential anti-carcinogens.
Among flavonoids, quercetin (Qu) is considered an excellent free-radical scavenging antioxidant, even if such an activity strongly depends on the intracellular availability of reduced glutathione.
Apart from antioxidant activity, Qu also exerts a direct, pro-apoptotic effect in tumor cells, and can indeed block the growth of several human cancer cell lines at different phases of the cell cycle.
Both these effects have been documented in a wide variety of cellular models as well as in animal models.
The high toxicity exerted by Qu on cancer cells perfectly matches with the almost total absence of any damages for normal, non-transformed cells.
In this review we discuss the molecular mechanisms that are based on the biological effects of Qu, and their relevance for human health.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gibellini, Lara& Pinti, Marcello& Nasi, Milena& Montagna, Jonas P.& De Biasi, Sara& Roat, Erika…[et al.]. 2011. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-483326
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gibellini, Lara…[et al.]. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-483326
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gibellini, Lara& Pinti, Marcello& Nasi, Milena& Montagna, Jonas P.& De Biasi, Sara& Roat, Erika…[et al.]. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-483326
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483326
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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