Quercetin and Cancer Chemoprevention
Joint Authors
Nasi, Milena
Bertoncelli, Linda
Gibellini, Lara
Montagna, Jonas P.
De Biasi, Sara
Roat, Erika
Cooper, Edwin L.
Cossarizza, Andrea
Pinti, Marcello
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Several molecules present in the diet, including flavonoids, can inhibit the growth of cancer cells with an ability to act as “chemopreventers”.
Their cancer-preventive effects have been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis as well as the antioxidant functions.
The antioxidant activity of chemopreventers has recently received a great interest, essentially because oxidative stress participates in the initiation and progression of different pathological conditions, including cancer.
Since antioxidants are capable of preventing oxidative damage, the wide use of natural food-derived antioxidants is receiving greater attention as potential anti-carcinogens.
Among flavonoids, quercetin (Qu) is considered an excellent free-radical scavenging antioxidant, even if such an activity strongly depends on the intracellular availability of reduced glutathione.
Apart from antioxidant activity, Qu also exerts a direct, pro-apoptotic effect in tumor cells, and can indeed block the growth of several human cancer cell lines at different phases of the cell cycle.
Both these effects have been documented in a wide variety of cellular models as well as in animal models.
The high toxicity exerted by Qu on cancer cells perfectly matches with the almost total absence of any damages for normal, non-transformed cells.
In this review we discuss the molecular mechanisms that are based on the biological effects of Qu, and their relevance for human health.
American Psychological Association (APA)
Gibellini, Lara& Pinti, Marcello& Nasi, Milena& Montagna, Jonas P.& De Biasi, Sara& Roat, Erika…[et al.]. 2011. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-483326
Modern Language Association (MLA)
Gibellini, Lara…[et al.]. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-483326
American Medical Association (AMA)
Gibellini, Lara& Pinti, Marcello& Nasi, Milena& Montagna, Jonas P.& De Biasi, Sara& Roat, Erika…[et al.]. Quercetin and Cancer Chemoprevention. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-483326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483326