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Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
المؤلفون المشاركون
Kumar, Gopinatha Suresh
Maiti, Motilal
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-12-15
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
Bioactive alkaloids occupy an important position in applied chemistry and play an indispensable role in medicinal chemistry.
Amongst them, isoquinoline alkaloids like berberine, palmatine and coralyne of protoberberine group, sanguinarine of the benzophenanthridine group, and their derivatives represent an important class of molecules for their broad range of clinical and pharmacological utility.
In view of their extensive occurrence in various plant species and significantly low toxicities, prospective development and use of these alkaloids as effective anticancer agents are matters of great current interest.
This review has focused on the interaction of these alkaloids with polymorphic nucleic acid structures (B-form, A-form, Z-form, HL-form, triple helical form, quadruplex form) and their topoisomerase inhibitory activity reported by several research groups using various biophysical techniques like spectrophotometry, spectrofluorimetry, thermal melting, circular dichroism, NMR spectroscopy, electrospray ionization mass spectroscopy, viscosity, isothermal titration calorimetry, differential scanning calorimetry, molecular modeling studies, and so forth, to elucidate their mode and mechanism of action for structure-activity relationships.
The DNA binding of the planar sanguinarine and coralyne are found to be stronger and thermodynamically more favoured compared to the buckled structure of berberine and palmatine and correlate well with the intercalative mechanism of sanguinarine and coralyne and the partial intercalation by berberine and palmatine.
Nucleic acid binding properties are also interpreted in relation to their anticancer activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maiti, Motilal& Kumar, Gopinatha Suresh. 2009. Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-23.
https://search.emarefa.net/detail/BIM-483533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maiti, Motilal& Kumar, Gopinatha Suresh. Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer. Journal of Nucleic Acids No. 2010 (2010), pp.1-23.
https://search.emarefa.net/detail/BIM-483533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maiti, Motilal& Kumar, Gopinatha Suresh. Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer. Journal of Nucleic Acids. 2009. Vol. 2010, no. 2010, pp.1-23.
https://search.emarefa.net/detail/BIM-483533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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