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Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
Joint Authors
Kumar, Gopinatha Suresh
Maiti, Motilal
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-15
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Bioactive alkaloids occupy an important position in applied chemistry and play an indispensable role in medicinal chemistry.
Amongst them, isoquinoline alkaloids like berberine, palmatine and coralyne of protoberberine group, sanguinarine of the benzophenanthridine group, and their derivatives represent an important class of molecules for their broad range of clinical and pharmacological utility.
In view of their extensive occurrence in various plant species and significantly low toxicities, prospective development and use of these alkaloids as effective anticancer agents are matters of great current interest.
This review has focused on the interaction of these alkaloids with polymorphic nucleic acid structures (B-form, A-form, Z-form, HL-form, triple helical form, quadruplex form) and their topoisomerase inhibitory activity reported by several research groups using various biophysical techniques like spectrophotometry, spectrofluorimetry, thermal melting, circular dichroism, NMR spectroscopy, electrospray ionization mass spectroscopy, viscosity, isothermal titration calorimetry, differential scanning calorimetry, molecular modeling studies, and so forth, to elucidate their mode and mechanism of action for structure-activity relationships.
The DNA binding of the planar sanguinarine and coralyne are found to be stronger and thermodynamically more favoured compared to the buckled structure of berberine and palmatine and correlate well with the intercalative mechanism of sanguinarine and coralyne and the partial intercalation by berberine and palmatine.
Nucleic acid binding properties are also interpreted in relation to their anticancer activity.
American Psychological Association (APA)
Maiti, Motilal& Kumar, Gopinatha Suresh. 2009. Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-23.
https://search.emarefa.net/detail/BIM-483533
Modern Language Association (MLA)
Maiti, Motilal& Kumar, Gopinatha Suresh. Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer. Journal of Nucleic Acids No. 2010 (2010), pp.1-23.
https://search.emarefa.net/detail/BIM-483533
American Medical Association (AMA)
Maiti, Motilal& Kumar, Gopinatha Suresh. Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer. Journal of Nucleic Acids. 2009. Vol. 2010, no. 2010, pp.1-23.
https://search.emarefa.net/detail/BIM-483533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483533