Long-Term Use of Probiotic-Containing Yogurts Is a Safe Way to Prevent Helicobacter pylori : Based on a Mongolian Gerbil's Model

الملخص EN

Background.

The suppression of Helicobacter pylori (H.

pylori) decreases H.

pylori-related diseases.

The probiotics have an inhibitory effect on H.

pylori.

Aim.

We investigated the effects of long-term use of yogurt on H.

pylori based on Mongolian gerbils’ model.

Materials and Methods.

Yogurt (containing a supplement of Lactobacillus acidophilus, Bifidobacterium lactis, etc.) was used.

Forty-six gerbils were divided into five groups.

All groups were inoculated with H.

pylori for 5 to 8 weeks.

The yogurt was given as follows: Group (Gr.) A: from 1st to 4th week; Gr.

B from 5th to 8th week; Gr.

C: from 17th week to sacrifice; Gr.

D: from 5th week to sacrifice.

Gerbils were sacrificed on the 52nd week.

Histology was evaluated according to the Sydney system.

Results.

The positive rates of H.

pylori were 60% (Gr.

A), 75% (Gr.

B), 67% (Gr.

C), 44% (Gr.

D), and 100% (Gr.

E).

Gr.

D showed lower inflammatory score.

Only Gr.

E (60%) had intestinal metaplasia.

Gr.

D showed higher IL-10 and lower TNF-α expression than Gr.

E.

Conclusion.

Long-term intake of yogurt could decrease H.

pylori infection.

The long-term use of yogurt would be an alternative strategy to manage H.

pylori infection.