![](/images/graphics-bg.png)
The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts
المؤلفون المشاركون
Su, Shu-Jem
Shyu, Huey-Wen
Yeh, Yao-Tsung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Biochanin A (BCA) is a major isoflavone abundant in red clover (Trifolium pretense).
The protective effect of BCA on bone loss in an ovariectomized (OVX) animal model has never been clarified.
The objective of this study was to investigate the biological effects of BCA on bone loss in OVX rats in vivo and on the development of osteoblasts and osteoclasts in vitro.
Ovariectomy resulted in a marked increase in body weight and a decrease in femoral bone mineral density and trabecular bone volume that was prevented by BCA or 17β-estradiol (E2) treatment.
However, an increase in uterine weight was observed in E2-treated OVX rats, but not in response to BCA treatment.
Treatment with BCA increased the mRNA expression of osterix, collagen type I, alkaline phosphatase (ALP), and osteocalcin and decreased the mRNA expression of tartrate-resistant acid phosphatase (TRAP) and the receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) ratio in the femur of OVX rats.
Treatment with BCA or E2 prevented the OVX-induced increase in urinary deoxypyridinoline (DPD) and serum tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β).
In vitro, BCA induced preosteoblasts to differentiate into osteoblasts and increased osteoblast mineralization.
BCA inhibited preosteoclasts and osteoclast proliferation and decreased osteoclast bone resorption.
These findings suggest that BCA treatment can effectively prevent the OVX-induced increase in bone loss and bone turnover possibly by increasing osteoblastic activities and decreasing osteoclastic activities.Erratum to “The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats: Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts”dx.doi.org/10.1155/2013/149764
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Shu-Jem& Yeh, Yao-Tsung& Shyu, Huey-Wen. 2013. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-483665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Shu-Jem…[et al.]. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-483665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Shu-Jem& Yeh, Yao-Tsung& Shyu, Huey-Wen. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-483665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)