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The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts
Joint Authors
Su, Shu-Jem
Shyu, Huey-Wen
Yeh, Yao-Tsung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Biochanin A (BCA) is a major isoflavone abundant in red clover (Trifolium pretense).
The protective effect of BCA on bone loss in an ovariectomized (OVX) animal model has never been clarified.
The objective of this study was to investigate the biological effects of BCA on bone loss in OVX rats in vivo and on the development of osteoblasts and osteoclasts in vitro.
Ovariectomy resulted in a marked increase in body weight and a decrease in femoral bone mineral density and trabecular bone volume that was prevented by BCA or 17β-estradiol (E2) treatment.
However, an increase in uterine weight was observed in E2-treated OVX rats, but not in response to BCA treatment.
Treatment with BCA increased the mRNA expression of osterix, collagen type I, alkaline phosphatase (ALP), and osteocalcin and decreased the mRNA expression of tartrate-resistant acid phosphatase (TRAP) and the receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) ratio in the femur of OVX rats.
Treatment with BCA or E2 prevented the OVX-induced increase in urinary deoxypyridinoline (DPD) and serum tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β).
In vitro, BCA induced preosteoblasts to differentiate into osteoblasts and increased osteoblast mineralization.
BCA inhibited preosteoclasts and osteoclast proliferation and decreased osteoclast bone resorption.
These findings suggest that BCA treatment can effectively prevent the OVX-induced increase in bone loss and bone turnover possibly by increasing osteoblastic activities and decreasing osteoclastic activities.Erratum to “The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats: Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts”dx.doi.org/10.1155/2013/149764
American Psychological Association (APA)
Su, Shu-Jem& Yeh, Yao-Tsung& Shyu, Huey-Wen. 2013. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-483665
Modern Language Association (MLA)
Su, Shu-Jem…[et al.]. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-483665
American Medical Association (AMA)
Su, Shu-Jem& Yeh, Yao-Tsung& Shyu, Huey-Wen. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats : Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-483665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483665