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Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
المؤلفون المشاركون
Lin, Kuan-Hung
Chen, Wei-Fan
Hsieh, Cheng-Ying
Chang, Chao-Chien
Chang, Yi
Chou, Duen-Suey
Lin, Li-Jyun
Sheu, Joen-Rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Pomegranates are widely consumed either as fresh fruit or in beverage form as juice and wine.
Ellagic acid possesses potent antioxidative properties; it is known to be an effective phytotherapeutic agent with antimutagenic and anticarcinogenic qualities.
Ellagic acid (20 to 80 μM) exhibited a potent activity in inhibiting platelet aggregation stimulated by collagen; however, it did not inhibit platelet aggregation stimulated by thrombin, arachidonic acid, or U46619.
Treatment with ellagic acid (50 and 80 μM) significantly inhibited platelet activation stimulated by collagen; this alteration was accompanied by the inhibition of relative [Ca2+]i mobilization, and the phosphorylation of phospholipase C (PLC)γ2, protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and Akt, as well as hydroxyl radical (OH●) formation.
In addition, ellagic acid also inhibited p38 MAPK and Akt phosphorylation stimulated by hydrogen peroxide.
By contrast, ellagic acid did not significantly affect PKC activation and platelet aggregation stimulated by PDBu.
This study is the first to show that, in addition to being considered a possible agent for preventing tumor growth, ellagic acid possesses potent antiplatelet properties.
It appears to initially inhibit the PLCγ2-PKC cascade and/or hydroxyl radical formation, followed by decreased phosphorylation of MAPKs and Akt, ultimately inhibiting platelet aggregation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Yi& Chen, Wei-Fan& Lin, Kuan-Hung& Hsieh, Cheng-Ying& Chou, Duen-Suey& Lin, Li-Jyun…[et al.]. 2013. Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483691
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Yi…[et al.]. Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-483691
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Yi& Chen, Wei-Fan& Lin, Kuan-Hung& Hsieh, Cheng-Ying& Chou, Duen-Suey& Lin, Li-Jyun…[et al.]. Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483691
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483691
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