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Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
Joint Authors
Lin, Kuan-Hung
Chen, Wei-Fan
Hsieh, Cheng-Ying
Chang, Chao-Chien
Chang, Yi
Chou, Duen-Suey
Lin, Li-Jyun
Sheu, Joen-Rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pomegranates are widely consumed either as fresh fruit or in beverage form as juice and wine.
Ellagic acid possesses potent antioxidative properties; it is known to be an effective phytotherapeutic agent with antimutagenic and anticarcinogenic qualities.
Ellagic acid (20 to 80 μM) exhibited a potent activity in inhibiting platelet aggregation stimulated by collagen; however, it did not inhibit platelet aggregation stimulated by thrombin, arachidonic acid, or U46619.
Treatment with ellagic acid (50 and 80 μM) significantly inhibited platelet activation stimulated by collagen; this alteration was accompanied by the inhibition of relative [Ca2+]i mobilization, and the phosphorylation of phospholipase C (PLC)γ2, protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and Akt, as well as hydroxyl radical (OH●) formation.
In addition, ellagic acid also inhibited p38 MAPK and Akt phosphorylation stimulated by hydrogen peroxide.
By contrast, ellagic acid did not significantly affect PKC activation and platelet aggregation stimulated by PDBu.
This study is the first to show that, in addition to being considered a possible agent for preventing tumor growth, ellagic acid possesses potent antiplatelet properties.
It appears to initially inhibit the PLCγ2-PKC cascade and/or hydroxyl radical formation, followed by decreased phosphorylation of MAPKs and Akt, ultimately inhibiting platelet aggregation.
American Psychological Association (APA)
Chang, Yi& Chen, Wei-Fan& Lin, Kuan-Hung& Hsieh, Cheng-Ying& Chou, Duen-Suey& Lin, Li-Jyun…[et al.]. 2013. Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483691
Modern Language Association (MLA)
Chang, Yi…[et al.]. Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-483691
American Medical Association (AMA)
Chang, Yi& Chen, Wei-Fan& Lin, Kuan-Hung& Hsieh, Cheng-Ying& Chou, Duen-Suey& Lin, Li-Jyun…[et al.]. Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483691