Gastrointestinal Stromal Tumors : A Review of Case Reports, Diagnosis, Treatment, and Future Directions
المؤلفون المشاركون
Mustacchia, Paul J.
Tan, Christopher B.
Zhi, Wanqing
Shahzad, Ghulamullah
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-12
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Gastrointestinal stromal tumor (GIST) is a nonepithelial, mesenchymal tumor first described by Mazur and Clark in 1983.
Since then, its molecular biology has been studied in great detail.
Special interest in the role of tyrosine kinase in its regulation has been the target by different drug research.
Mutation in c-kit exons 9, 11, 13, 17 and PDGFRA mutation in exons 12, 14, 18 are responsible for activation of gene signaling system resulting in uncontrolled phosphorylation and tissue growth.
However, 5 to 15% of GISTs does not harbor these mutations, which raises additional questions in another alternate signaling pathway mutation yet to be discovered.
Diagnosis of GISTs relies heavily on KIT/CD117 immunohistochemical staining, which can detect most GISTs except for a few 3% to 5% that harbors PDGFRA mutation.
Newer staining against PKC theta and DOG-1 genes showed promising results but are not readily available.
Clinical manifestation of GISTs is broad and highly dependent on tumor size.
Surgery still remains the first-line treatment for GISTs.
The advancement of molecular biology has revolutionized the availability of newer drugs, Imatinib and Sunitinib.
Together with its advancement is the occurrence of Imatinib/Sunitinib drug resistance.
With this, newer monoclonal antibody drugs are being developed and are undergoing clinical trials to hopefully improve survival in patients with GISTs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Christopher B.& Zhi, Wanqing& Shahzad, Ghulamullah& Mustacchia, Paul J.. 2012. Gastrointestinal Stromal Tumors : A Review of Case Reports, Diagnosis, Treatment, and Future Directions. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-483757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Christopher B.…[et al.]. Gastrointestinal Stromal Tumors : A Review of Case Reports, Diagnosis, Treatment, and Future Directions. ISRN Gastroenterology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-483757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Christopher B.& Zhi, Wanqing& Shahzad, Ghulamullah& Mustacchia, Paul J.. Gastrointestinal Stromal Tumors : A Review of Case Reports, Diagnosis, Treatment, and Future Directions. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-483757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر