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Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach
المؤلفون المشاركون
Descombes, Eric
Fellay, Benoit
Hemett, Ould Maouloud
Magnin, Jean-Luc
Fellay, Gilbert
المصدر
International Journal of Nephrology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of the present study was to evaluate the dose of postdialysis cholecalciferol needed to maintain the 25-hydroxyvitamin D [25(OH)D] levels in the optimal range of 75–150 nmol/L.
Twenty-six patients who had low baseline 25(OH)D levels (mean 27.5±14.9 nmol/L) were studied.
The 25(OH)D levels were measured every 2 months for one year.
During the first two months, all the patients received 2000 IU of cholecalciferol after each hemodialysis (=6000 IU/wk).
Thereafter, the dose was individualized and adapted every 2 months by administering 1 to 6 cholecalciferol tablets (2000 IU each) per week (total weekly dose = 2000–12000 IU/wk).
During cholecalciferol supplementation, the 25(OH)D concentrations rapidly increased from baseline to 140.1±28.3 nmol/L at month 6 and 95.6±20.9 nmol/L at month 12.
At month twelve, 86% of the patients had 25(OH)D levels within the target range with a mean dose of 5917±4106 IU/wk of cholecalciferol; however, the amount needed to maintain these levels varied widely from 0 (n=2) to 12000 IU/wk (n=5).
In conclusion, postdialysis cholecalciferol prescription is quite effective in correcting vitamin D deficiency/insufficiency, but the amount of cholecalciferol needed to maintain the 25(OH)D levels within the optimal range over the long-term varies widely among patients and must be individualized.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Descombes, Eric& Fellay, Benoit& Hemett, Ould Maouloud& Magnin, Jean-Luc& Fellay, Gilbert. 2014. Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-483903
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Descombes, Eric…[et al.]. Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach. International Journal of Nephrology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-483903
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Descombes, Eric& Fellay, Benoit& Hemett, Ould Maouloud& Magnin, Jean-Luc& Fellay, Gilbert. Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-483903
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483903
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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