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Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach
Joint Authors
Descombes, Eric
Fellay, Benoit
Hemett, Ould Maouloud
Magnin, Jean-Luc
Fellay, Gilbert
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the present study was to evaluate the dose of postdialysis cholecalciferol needed to maintain the 25-hydroxyvitamin D [25(OH)D] levels in the optimal range of 75–150 nmol/L.
Twenty-six patients who had low baseline 25(OH)D levels (mean 27.5±14.9 nmol/L) were studied.
The 25(OH)D levels were measured every 2 months for one year.
During the first two months, all the patients received 2000 IU of cholecalciferol after each hemodialysis (=6000 IU/wk).
Thereafter, the dose was individualized and adapted every 2 months by administering 1 to 6 cholecalciferol tablets (2000 IU each) per week (total weekly dose = 2000–12000 IU/wk).
During cholecalciferol supplementation, the 25(OH)D concentrations rapidly increased from baseline to 140.1±28.3 nmol/L at month 6 and 95.6±20.9 nmol/L at month 12.
At month twelve, 86% of the patients had 25(OH)D levels within the target range with a mean dose of 5917±4106 IU/wk of cholecalciferol; however, the amount needed to maintain these levels varied widely from 0 (n=2) to 12000 IU/wk (n=5).
In conclusion, postdialysis cholecalciferol prescription is quite effective in correcting vitamin D deficiency/insufficiency, but the amount of cholecalciferol needed to maintain the 25(OH)D levels within the optimal range over the long-term varies widely among patients and must be individualized.
American Psychological Association (APA)
Descombes, Eric& Fellay, Benoit& Hemett, Ould Maouloud& Magnin, Jean-Luc& Fellay, Gilbert. 2014. Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-483903
Modern Language Association (MLA)
Descombes, Eric…[et al.]. Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach. International Journal of Nephrology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-483903
American Medical Association (AMA)
Descombes, Eric& Fellay, Benoit& Hemett, Ould Maouloud& Magnin, Jean-Luc& Fellay, Gilbert. Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis : A Dose-Response Approach. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-483903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483903