Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin
المؤلفون المشاركون
Lescai, Francesco
Antonicelli, Roberto
Spazzafumo, Liana
Provinciali, Mauro
Marchegiani, Francesca
Cardelli, Maurizio
Franceschi, Claudio
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
It is well known that serum paraoxonase (PON1) plays an important role in the protection of LDL from oxidation.
PON1 55 polymorphism is currently investigated for its possible involvement in cardiovascular diseases.
The objective of our study is to verify if PON1 55 polymorphism is associated with risk of acute coronary syndrome (ACS) and with biochemical myocardial ischemia markers, such as troponin I, creatine kinase (CK)-MB, myoglobin, and C-reactive protein.
We analysed PON1 55 polymorphism in a total of 440 elderly patients who underwent an ACS episode: 98 patients affected by unstable angina (UA), 207 AMI (acute myocardial infarction) patients affected by STEMI (ST elevation), and 135 AMI patients affected by NSTEMI (no ST elevation).
We found that individuals carrying PON1 55 LL genotype are significantly more represented among AMI patients affected by NSTEMI; moreover, the patients carrying LL genotype showed significantly higher levels of myoglobin in comparison to LM + MM carriers patients.
Our study suggests that PON1 55 polymorphism could play a role in the pathogenesis of cardiac ischemic damage.
In particular, the significant association between PON1 55 LL genotype and the occurrence of a NSTEMI may contribute to improve the stratification of the cardiovascular risk within a population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marchegiani, Francesca& Spazzafumo, Liana& Cardelli, Maurizio& Provinciali, Mauro& Lescai, Francesco& Franceschi, Claudio…[et al.]. 2012. Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin. Journal of Lipids،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marchegiani, Francesca…[et al.]. Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin. Journal of Lipids No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-484137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marchegiani, Francesca& Spazzafumo, Liana& Cardelli, Maurizio& Provinciali, Mauro& Lescai, Francesco& Franceschi, Claudio…[et al.]. Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر