Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin
Joint Authors
Lescai, Francesco
Antonicelli, Roberto
Spazzafumo, Liana
Provinciali, Mauro
Marchegiani, Francesca
Cardelli, Maurizio
Franceschi, Claudio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
It is well known that serum paraoxonase (PON1) plays an important role in the protection of LDL from oxidation.
PON1 55 polymorphism is currently investigated for its possible involvement in cardiovascular diseases.
The objective of our study is to verify if PON1 55 polymorphism is associated with risk of acute coronary syndrome (ACS) and with biochemical myocardial ischemia markers, such as troponin I, creatine kinase (CK)-MB, myoglobin, and C-reactive protein.
We analysed PON1 55 polymorphism in a total of 440 elderly patients who underwent an ACS episode: 98 patients affected by unstable angina (UA), 207 AMI (acute myocardial infarction) patients affected by STEMI (ST elevation), and 135 AMI patients affected by NSTEMI (no ST elevation).
We found that individuals carrying PON1 55 LL genotype are significantly more represented among AMI patients affected by NSTEMI; moreover, the patients carrying LL genotype showed significantly higher levels of myoglobin in comparison to LM + MM carriers patients.
Our study suggests that PON1 55 polymorphism could play a role in the pathogenesis of cardiac ischemic damage.
In particular, the significant association between PON1 55 LL genotype and the occurrence of a NSTEMI may contribute to improve the stratification of the cardiovascular risk within a population.
American Psychological Association (APA)
Marchegiani, Francesca& Spazzafumo, Liana& Cardelli, Maurizio& Provinciali, Mauro& Lescai, Francesco& Franceschi, Claudio…[et al.]. 2012. Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin. Journal of Lipids،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484137
Modern Language Association (MLA)
Marchegiani, Francesca…[et al.]. Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin. Journal of Lipids No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-484137
American Medical Association (AMA)
Marchegiani, Francesca& Spazzafumo, Liana& Cardelli, Maurizio& Provinciali, Mauro& Lescai, Francesco& Franceschi, Claudio…[et al.]. Paraoxonase-1 55 LL Genotype Is Associated with No ST-Elevation Myocardial Infarction and with High Levels of Myoglobin. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484137