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Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats
المؤلفون المشاركون
Tzaan, Wen-Ching
Chen, Hsien-Chih
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-11-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Intervertebral disc (IVD) degeneration is a multifactorial process that is influenced by contributions from genetic predisposition, the aging phenomenon, lifestyle conditions, biomechanical loading and activities, and other health factors (such as diabetes).
Attempts to decelerate disc degeneration using various techniques have been reported.
However, to date, there has been no proven technique effective for broad clinical application.
Granulocyte colony-stimulating factor (GCSF) is a growth factor cytokine that has been shown to enhance the availability of circulating hematopoietic stem cells to the brain and heart as well as their capacity for mobilization of mesenchymal bone marrow stem cells.
GCSF also exerts significant increases in circulating neutrophils as well as potent anti-inflammatory effects.
In our study, we hypothesize that GCSF can induce bone marrow stem cells differentiation and mobilization to regenerate the degenerated IVD.
We found that GCSF had no contribution in disc regeneration or maintenance; however, there were cell proliferation within end plates.
The effects of GCSF treatment on end plates might deserve further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tzaan, Wen-Ching& Chen, Hsien-Chih. 2010. Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats. Advances in Orthopedics،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tzaan, Wen-Ching& Chen, Hsien-Chih. Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats. Advances in Orthopedics No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-484163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tzaan, Wen-Ching& Chen, Hsien-Chih. Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats. Advances in Orthopedics. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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